Journal of Applied Dental
and Medical Sciences
Journal of Applied Dental and Medical Sciences is A Quarterly Published


Simvastatin Collagen Graft In the surgical management of Mandibular Class II Furcation Defects

Shivali S. Gaekwad, Gauresh Kumar Patel, Sheela Kumar Gujjari, Pramod kumar T.M


Background: The management of multi-rooted teeth affected by periodontal disease has remained a challenge. Local application of Simvastatin stimulates bone formation by expression of Bone morphogenetic protein-2 and also promotes periodontal healing. The present study evaluates the benefits of ‘Simvastatin collagen graft’ in comparison to ‘collagen graft’ in the surgical management of class II furcation involved teeth. Materials and Methods: Employing a split mouth design, a total of 40 bilateral mandibular class II furcation defects in 20 systemically healthy subjects were randomized as test and control sites. Simvastatin collagen graft was placed in the test sites and collagen graft was placed in the control sites. Clinical parameters including site specific plaque index, gingival index, bleeding index, probing depth and clinical attachment level were recorded at baseline, 6 months, 9 months 12 months and 15 months. Radiographic assessment of bone fill was made using standardized intraoral periapical radiographs with an X- ray mesh gauge taken at baseline, 6, 9, 12 and 15 months. The results were analyzed statistically. Results: A statistically significant decrease in probing pocket depth and improved clinical attachment level was observed in both groups over 15 months, but comparisons between the test and control groups did not show statistically significant differences. Radiographic analysis showed bone formation. The percentage bone area between the test and control over 15 months showed statistically significant differences. Conclusion: Simvastatin collagen graft and collagen graft both showed improvements in clinical parameters and evidence of bone formation. The results encourage the adjunctive use of Simvastatin collagen graft for predictable regeneration of grade II furcation defects.

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