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ABSTRACT
Stromal Players In Carcinogenesis
Himanta Ghritlahare, Swatantra Patel
ABSTRACT
Tumor cells alter the surrounding stroma and in turn, the stromal cells may promote cancer progression and invasion. This is carried out by stromal cell like carcinoma-associated fibroblasts (CAFs), tumor associated macrophages (TAMs), endothelial cells (ECs), leucocytes, and bone marrow derived cells. While none of these cells are themselves malignant, owing to their environment and owing to their interaction with each other and directly/indirectly with the cancer cell, they acquire an abnormal phenotype and altered function. In this review paper, we will discuss in detail the various cellular and molecular components of stromal environment, their effect on cancer cells, and aspects of targeting this environment for control of cancer.
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